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Expertise
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Work
Work
With J.A. Boylan, C. Hummel, S. Benoit, J. Garcia-Lara, J. Treglown, and F.C. Gherardini, 鈥淚dentification of a Coenzyme A Disulfide Reductase from Borrelia Burgdorferi,鈥 Molecular Microbiology 59:475-486, 2006
With C.S. Hummel and K.M. Lancaster, 鈥淒etermination of coenzyme A levels in Pyrococcus furiosus and other Archaea: implications for a general role for coenzyme A in thermophiles,鈥 FEMS Microbiological Letters 252:229-234, 2005
With D.R. Harris, D. E. Ward, J. T. Feasel, K.M. Lancaster, R.D. Murphy, and T.C. Mallet, 鈥淒iscovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii: Implications for the disulfide metabolism of anaerobic hyperthermophiles,鈥 FEBS Journal 272:1189-1200, 2005
With C. Donnelly, M. Mullendrone, J. van der Oost, and W. de Vos, "The NADH Oxidase from Pyrococcus furiosus: Implications for the Protection of Anaerobic Hyperthermophiles Against Oxidative Stress," European Journal of Biochemistry, 2001
With J. Yeh, J. Luba and A. Claiborne, "Analysis of the Kinetic and Redox Properties of the NADH Peroxidase R303M Mutant: Correlation with the Crystal Structure," Biochemistry, 39, 10353-10364, 2000
With A. Claiborne, J. Yeh, T. Mallet, J. Luba, V. Charrier, and D. Parsonage, "Protein Sulfenic Acids: Diverse Roles for an Unlikely Player in Enzyme Catalysis and Redox Regulation," Biochemistry, 38, 15407-15416, 1999
With D.E. Ward, J. van der Oost, Q. She, and R. Garrett, "Sequence Analysis and Overexpression of Putative NADH Oxidases from the Hyperthermophilic Archaeons Sulfolobus Solfataricus and Pyrrococcus Horikoshii," in Flavins and Flavoproteins 1999 (S. Ghisla, P. Kroneck, P. Macheroux, and H. Sund, eds., Rudolf Weber, 1999)
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Education
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Awards & Honors
Awards & Honors
American Chemical Society, Petroleum Research Fund, (PI) $55,000 grant for 鈥淢echanisms of Sulfur Reduction by Sulfur/Polysulfide Reductase,鈥 2007-2010
U.S. Department of Energy, Genomes to Life Initiative, (CoPI) 鈥淚ntegrated Genome-Based Studies of Shewanella Ecophysiology, 2007-
6V电影网, Wig Distinguished Professorship Award for Excellence in Teaching, 2005
Cottrell College Science Award, Research Corporation; $40,000, (PI) 鈥淎 mechanistic study of thermophilic NADH oxidases from Pyrococcus: Are thermophilic and mesophilic catalytic structures different?鈥 2000-02; and $39,036, (PI) 鈥淓nzymatic mechanisms of control of internal redox environment in hyperthermophiles, 2003-05
Howard Hughes Medical Institute, Undergraduate Science Education Program (contributor), 2003-06
National Science Foundation, Major Research Grant Instrumentation Grant $235,780, (CoPI) 鈥淕enomic and Genetic Analysis Research in Molecular Biology at 6V电影网, 2003-06
Salisbury University, Distinguished Faculty Award, 1999; National Institutes of Health, National Research Service Award, 1994-1996; The Johns Hopkins University, Harry D. Kruse Award in Nutrition and Public Health, 1992